Autoimmune inflammation and disease creates an environment that results in defective regulatory T (Treg) cell functions. New data show how induction of Foxp3 expression in these Treg cells during ongoing autoimmune inflammation can restore control over pathogenic T cell functions and resolve inflammation and pathology in mice.
References
Ramsdell, F. & Ziegler, S. F. Nat. Rev. Immunol. 14, 343–349 (2014).
Gangaplara, A. et al. PLoS Pathog. 14, e1006985 (2018).
Laurence, A. et al. Immunity 26, 371–381 (2007).
Hu, W. et al. Nat. Immunol. https://doi.org/10.1038/s41590-021-01001-4 (2021).
Gavin, M. A. et al. Nature 445, 771–775 (2007).
Lin, W. et al. Nat. Immunol. 8, 359–368 (2007).
Bending, D. et al. EMBO J. https://doi.org/10.15252/embj.201899013 (2018).
Fontenot, J. D., Gavin, M. A. & Rudensky, A. Y. Nat. Immunol. 4, 330–336 (2003).
Levine, A. G., Arvey, A., Jin, W. & Rudensky, A. Y. Nat. Immunol. 15, 1070–1078 (2014).
Stadinski, B. D. et al. Nat. Immunol. 20, 1046–1058 (2019).
Acknowledgements
M.O. is supported by the MRC research grant MR/S000208/1.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Ono, M. Restoring control over autoimmunity by inducing Foxp3. Nat Immunol 22, 1080–1082 (2021). https://doi.org/10.1038/s41590-021-01008-x
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41590-021-01008-x
- Springer Nature America, Inc.