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MULTIPLE MYELOMA

Inflammatory stromal cells in the myeloma microenvironment

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Single-cell RNA sequencing identifies an inflammatory subpopulation of mesenchymal stromal cells in patients with multiple myeloma.

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Fig. 1: Model of the interaction between iMSCs and tumor and immune cells.

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Author information

Author notes

  1. These authors contributed equally: Romanos Sklavenitis-Pistofidis, Nicholas J. Haradhvala.

Authors and Affiliations

  1. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA

    Romanos Sklavenitis-Pistofidis & Irene M. Ghobrial

  2. Center for Prevention of Progression of Blood Cancers, Dana-Farber Cancer Institute, Boston, MA, USA

    Romanos Sklavenitis-Pistofidis & Irene M. Ghobrial

  3. Broad Institute of MIT and Harvard, Cambridge, MA, USA

    Romanos Sklavenitis-Pistofidis, Nicholas J. Haradhvala, Gad Getz & Irene M. Ghobrial

  4. Harvard Graduate Program in Biophysics, Harvard University, Cambridge, MA, USA

    Nicholas J. Haradhvala

  5. Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Gad Getz

Authors
  1. Romanos Sklavenitis-Pistofidis
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  2. Nicholas J. Haradhvala
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  3. Gad Getz
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  4. Irene M. Ghobrial
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Corresponding author

Correspondence to Irene M. Ghobrial.

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Competing interests

R.S.P. has no competing interests to disclose. N.J.H. is a consultant for Constellation Pharmaceuticals. I.M.G has a consulting and advisory role with Celgene, Takeda, Bristol-Myers Squibb, Genentech, Janssen Pharmaceuticals and Amgen and has received research funding/honoraria from Celgene, Takeda, Bristol-Myers Squibb, Janssen Pharmaceuticals and Amgen. G.G. receives research funds from IBM and Pharmacyclics and is an inventor on patent applications related to MuTect, ABSOLUTE, MutSig, MSMuTect, MSMutSig, MSIdetect, POLYSOLVER and TensorQTL. G.G. is a founder, consultant and holds privately held equity in Scorpion Therapeutics.

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Sklavenitis-Pistofidis, R., Haradhvala, N.J., Getz, G. et al. Inflammatory stromal cells in the myeloma microenvironment. Nat Immunol 22, 677–678 (2021). https://doi.org/10.1038/s41590-021-00947-9

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