Skip to main content
SpringerLink
Log in

INKT CELLS

Macrophages make the bed for early iNKT cells

  • News & Views
  • Published:

From Nature Immunology

View current issue Submit your manuscript

Colonization of the mucosal tissues by iNKT cells was thought to be linked to the first contact with the environment. New research demonstrates that this process is regulated by and dependent on embryonic macrophages.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Colon iNKT cell expansion in early life is dependent on embryonic macrophages.

References

  1. Lynch, L. et al. Nat. Immunol. 16, 85–95 (2015).

    Article  CAS  Google Scholar 

  2. Diana, J. et al. Immunity 30, 289–299 (2009).

    Article  CAS  Google Scholar 

  3. Crosby, C. M. & Kronenberg, M. Nat. Rev. Immunol. 18, 559–574 (2018).

    Article  CAS  Google Scholar 

  4. Gensollen, T. et al. Nat. Immunol. https://doi.org/10.1038/s41590-021-00934-0 (2021).

  5. Nieuwenhuis, E. E. S. et al. J. Clin. Invest. 119, 1241–1250 (2009).

    Article  CAS  Google Scholar 

  6. Olszak, T. et al. Science 336, 489–493 (2012).

    Article  CAS  Google Scholar 

  7. Olszak, T. et al. Nature 509, 497–502 (2014).

    Article  CAS  Google Scholar 

  8. Ginhoux, F. & Guilliams, M. Immunity 44, 439–449 (2016).

    Article  CAS  Google Scholar 

  9. Bain, C. C. et al. Nat. Immunol. 15, 929–937 (2014).

    Article  CAS  Google Scholar 

  10. Scott, C. L. et al. Nat. Commun. 7, 10321 (2016).

    Article  CAS  Google Scholar 

  11. Simoni, Y. et al. Eur. J. Immunol. 41, 3574–3585 (2011).

    Article  CAS  Google Scholar 

  12. Rubio, M.-T. et al. Blood 120, 2144–2154 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Université de Paris, Institut Cochin, INSERM U1016, CNRS UMR 8104, Paris, France

    Léo Bertrand, Amine Toubal & Agnès Lehuen

  2. Laboratoire d’Excellence Inflamex, Paris, France

    Léo Bertrand, Amine Toubal & Agnès Lehuen

Authors
  1. Léo Bertrand
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Amine Toubal
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Agnès Lehuen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Agnès Lehuen.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bertrand, L., Toubal, A. & Lehuen, A. Macrophages make the bed for early iNKT cells. Nat Immunol 22, 681–682 (2021). https://doi.org/10.1038/s41590-021-00938-w

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-021-00938-w

  • Springer Nature America, Inc.

Search

Navigation