Antigen escape by solid tumors has limited the efficacy of genetically modified T cells. T cells engineered to secrete the cytokine Flt3L induce the activation of endogenous T cells, enabling a broader repertoire of tumor antigens to be targeted via the expansion of intratumoral antigen presenting cells, significantly improving tumor responses.
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Morris, E.C. Engineered T cells Flt around their targets. Nat Immunol 21, 831–832 (2020). https://doi.org/10.1038/s41590-020-0740-3
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DOI: https://doi.org/10.1038/s41590-020-0740-3
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