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INFECTIOUS DISEASE

Plague as a cause for familial Mediterranean fever

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Evolutionary genetic and experimental analyses suggest that mutations causing familial Mediterranean fever have been positively selected in the Middle East, probably because they confer heightened resistance against Yersinia pestis infection.

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Fig. 1: Pyrin mutations causing familial Mediterranean fever are associated with increased release of proinflammatory cytokines upon Yersinia pestis infection.

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Acknowledgements

My laboratory is supported by the Institut Pasteur, the CNRS, the French Government’s Investissement d’Avenir program, Laboratoires d’Excellence “Integrative Biology of Emerging Infectious Diseases” (ANR-10-LABX-62-IBEID) and “Milieu Intérieur” (ANR-10-LABX-69-01) projects, the Fondation pour la Recherche Médicale (Equipe FRM DEQ20180339214) and the Agence Nationale de la Recherche grant ‘MORTUI’ (ANR-19-CE35-0005-01).

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  1. Human Evolutionary Genetics Unit, Institut Pasteur, UMR 2000, CNRS, Paris, France

    Etienne Patin

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  1. Etienne Patin
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Correspondence to Etienne Patin.

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Patin, E. Plague as a cause for familial Mediterranean fever. Nat Immunol 21, 833–834 (2020). https://doi.org/10.1038/s41590-020-0724-3

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  • DOI: https://doi.org/10.1038/s41590-020-0724-3

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