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Jack of all trades inhibits inflammation (in sober people)

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Caspase-cleaved gasdermin D forms pores in cellular membranes, thus executing proinflammatory cell death by pyroptosis. Disulfiram — a drug used to treat chronic alcoholism — is now found to be an inhibitor of pore formation, which may therapeutically counteract exacerbated inflammation in sepsis and beyond.

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Fig. 1: Mechanism of GSDMD inhibition.

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Acknowledgements

F.I.S. is funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) through the Emmy Noether Programme (SCHM 3336-1-1), SPP1923, SFB1403, TRR237 and Germany’s Excellence Strategy – EXC2151 – 390873048, as well as by the Klaus Tschira Boost Fund. E.L. is funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) through SPP1923, SFB1403, TRR237 and Germany’s Excellence Strategy – EXC2151 – 390873048.

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Authors and Affiliations

  1. Institute of Innate Immunity, Biomedical Center, Venusberg-Campus 1, University of Bonn, Bonn, Germany

    Florian I. Schmidt & Eicke Latz

  2. German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany

    Eicke Latz

  3. Department of Infectious Diseases and Immunology, UMass Medical School, Worcester, MA, USA

    Eicke Latz

Authors
  1. Florian I. Schmidt
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  2. Eicke Latz
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Correspondence to Florian I. Schmidt.

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Competing interests

E.L. is a cofounder of IFM Therapeutics. F.I.S. is a scientific consultant of IFM Therapeutics.

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Schmidt, F.I., Latz, E. Jack of all trades inhibits inflammation (in sober people). Nat Immunol 21, 718–719 (2020). https://doi.org/10.1038/s41590-020-0693-6

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