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NEUROIMMUNOLOGY

Tγδ17 cells build up the nerve

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γδ T cells are critical contributors to tissue homeostasis. Recent research identifies an unexpected role for γδ T cell–derived IL-17F in promoting sympathetic innervation and tissue thermogenesis through the induction of the cytokine TGF-β in adipose cells.

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Fig. 1: Model for crosstalk between Tγδ17 cells, adipocytes and sympathetic neurons in the regulation of brown adipose tissue (BAT) thermogenesis.

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Authors and Affiliations

  1. Department of Immunology, Duke University Medical Center, Durham, NC, USA

    Maria Ciofani

  2. Center for Advanced Genomic Technologies, Duke University, Durham, NC, USA

    Maria Ciofani

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  1. Maria Ciofani
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Correspondence to Maria Ciofani.

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Ciofani, M. Tγδ17 cells build up the nerve. Nat Immunol 21, 367–368 (2020). https://doi.org/10.1038/s41590-020-0642-4

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  • DOI: https://doi.org/10.1038/s41590-020-0642-4

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