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HIV-1 IMMUNITY

HIV-1-induced inflammation shapes innate immunity and induces adaptive traits in NK cells

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Chronic inflammation associated with HIV-1 infection disrupts the homeostasis of gut-resident innate lymphoid cells and induces the generation and expansion of adaptive NK cells expressing TCF7, a transcription factor that sustains their effector functions and memory-like properties.

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Fig. 1: HIV-1-associated inflammation alters the homeostasis of gut-resident and circulating lymphocytes.

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Authors and Affiliations

  1. Unit of Clinical and Experimental Immunology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy

    Joanna Mikulak, Clara Di Vito & Domenico Mavilio

  2. Department of Medical Biotechnologies and Translational Medicine (BioMeTra), University of Milan, Milan, Italy

    Joanna Mikulak, Clara Di Vito & Domenico Mavilio

Authors
  1. Joanna Mikulak
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  2. Clara Di Vito
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  3. Domenico Mavilio
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Corresponding author

Correspondence to Domenico Mavilio.

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The authors declare no competing interests.

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Mikulak, J., Di Vito, C. & Mavilio, D. HIV-1-induced inflammation shapes innate immunity and induces adaptive traits in NK cells. Nat Immunol 21, 245–247 (2020). https://doi.org/10.1038/s41590-020-0615-7

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