Skip to main content
SpringerLink
Log in

B cells

B is for ‘Big Mac’: GCs crave a high-fat diet

  • News & Views
  • Published:

From Nature Immunology

View current issue Submit your manuscript

Highly proliferative cells have classically been thought to rely on anaerobic glycolysis for fuel. Weisel et al. show that germinal center B cells break this rule, as they primarily utilize fatty acid oxidation to meet their metabolic demands.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Bioenergetics of germinal center B cells.

References

  1. MacLennan, I. C. Annu. Rev. Immunol. 12, 117–139 (1994).

    Article  CAS  Google Scholar 

  2. Allen, C. D., Okada, T., Tang, H. L. & Cyster, J. G. Science 315, 528–531 (2007).

    Article  CAS  Google Scholar 

  3. Gitlin, A. D. et al. Science 349, 643–646 (2015).

    Article  CAS  Google Scholar 

  4. Tas, J. M. et al. Science 351, 1048–1054 (2016).

    Article  CAS  Google Scholar 

  5. Weisel, F. J. et al. Nat. Immunol. https://doi.org/10.1038/s41590-020-0598-4 (2020).

    Article  PubMed  Google Scholar 

  6. Liu, Y. J. et al. Nature 342, 929–931 (1989).

    Article  CAS  Google Scholar 

  7. Vander Heiden, M. G., Cantley, L. C. & Thompson, C. B. Science 324, 1029–1033 (2009).

    Article  Google Scholar 

  8. Victora, G. D. et al. Cell 143, 592–605 (2010).

    Article  CAS  Google Scholar 

  9. Dominguez-Sola, D. et al. Nat. Immunol. 13, 1083–1091 (2012).

    Article  CAS  Google Scholar 

  10. Calado, D. P. et al. Nat. Immunol. 13, 1092–1100 (2012).

    Article  CAS  Google Scholar 

  11. Ersching, J. et al. Immunity 46, 1045–1058.e6 (2017).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA

    Juhee Pae & Gabriel D. Victora

Authors
  1. Juhee Pae
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gabriel D. Victora
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Gabriel D. Victora.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Pae, J., Victora, G.D. B is for ‘Big Mac’: GCs crave a high-fat diet. Nat Immunol 21, 249–250 (2020). https://doi.org/10.1038/s41590-020-0614-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-020-0614-8

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation