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TUMOR IMMUNOLOGY

CD36 — the Achilles’ heel of Treg cells

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Regulatory T (Treg) cells suppress antitumor immunity, but Treg cell inhibition has been hampered by a lack of specific targets. CD36 expression by tumor-infiltrating Treg cells may provide a way to specifically target Treg cells in tumors.

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Fig. 1: Treg cells suppress effector T cells in the tumor microenvironment and in healthy tissues.

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Authors and Affiliations

  1. Koch Institute for Cancer Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA

    Brendan L. Horton & Stefani Spranger

  2. Biology Department, Massachusetts Institute of Technology, Cambridge, MA, USA

    Stefani Spranger

  3. Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA

    Stefani Spranger

Authors
  1. Brendan L. Horton
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  2. Stefani Spranger
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Correspondence to Stefani Spranger.

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The authors declare no competing interests.

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Horton, B.L., Spranger, S. CD36 — the Achilles’ heel of Treg cells. Nat Immunol 21, 251–253 (2020). https://doi.org/10.1038/s41590-020-0601-0

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