Skip to main content
SpringerLink
Log in

TRANSCRIPTIONAL REGULATION

Gene regulatory networks STARR-ing B cells

  • News & Views
  • Published:

From Nature Immunology

View current issue Submit your manuscript

  • 7 Altmetric

A genome-wide screening of functionally active enhancers, combined with analyses of chromatin features, transcription factor binding and gene expression, reveals general principles of gene regulatory networks in activated B cells.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: High-throughput analyses of regulatory features define general characteristics of gene regulatory networks in LPS-activated B cells.

References

  1. Chaudhri, V. K., Dienger-Stambaugh, K., Wu, Z., Shrestha, M. & Singh, H. Nat. Immunol. https://doi.org/10.1038/s41590-019-0565-0 (2020).

    Article  Google Scholar 

  2. Banerji, J., Olson, L. & Schaffner, W. Cell 33, 729–740 (1983).

    Article  CAS  Google Scholar 

  3. Gillies, S. D., Morrison, S. L., Oi, V. T. & Tonegawa, S. Cell 33, 717–728 (1983).

    Article  CAS  Google Scholar 

  4. Pettersson, S., Cook, G. P., Brüggemann, M., Williams, G. T. & Neuberger, M. S. Nature 344, 165–168 (1990).

    Article  CAS  Google Scholar 

  5. Dunham, I. et al. Nature 489, 57–74 (2012).

    Article  CAS  Google Scholar 

  6. Yoshida, H. et al. Cell 176, 897–912.e20 (2019).

    Article  CAS  Google Scholar 

  7. Giresi, P. G., Kim, J., McDaniell, R. M., Iyer, V. R. & Lieb, J. D. Genome Res. 17, 877–885 (2007).

    Article  CAS  Google Scholar 

  8. Song, L. & Crawford, G. E. Cold Spring Harb. Protoc. https://doi.org/10.1101/pdb.prot5384 (2010).

    Article  Google Scholar 

  9. Buenrostro, J. D., Giresi, P. G., Zaba, L. C., Chang, H. Y. & Greenleaf, W. J. Nat. Methods 10, 1213–1218 (2013).

    Article  CAS  Google Scholar 

  10. Sanjana, N. E. et al. F. Science 353, 1545–1549 (2016).

    Article  CAS  Google Scholar 

  11. Murtha, M. et al. Nat. Methods 11, 559–565 (2014).

    Article  CAS  Google Scholar 

  12. Arnold, C. D. et al. Science 339, 1074–1077 (2013).

    Article  CAS  Google Scholar 

  13. Lieberman-Aiden, E. et al. Science 326, 289–293 (2009).

    Article  CAS  Google Scholar 

  14. Sabari, B. R. et al. Science 361, eaar3958 (2018).

    Article  Google Scholar 

  15. Cho, W. K. et al. Science 361, 412–415 (2018).

    Article  CAS  Google Scholar 

  16. Boija, A. et al. Cell 175, 1842–1855.e16 (2018).

    Article  CAS  Google Scholar 

  17. Whyte, W. A. et al. Cell 153, 307–319 (2013).

    Article  CAS  Google Scholar 

  18. Shrinivas, K. et al. Mol. Cell 75, 549–561.e7 (2019).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine and Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine, New York, NY, USA

    Alexia Martínez de Paz & Steven Zvi Josefowicz

Authors
  1. Alexia Martínez de Paz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Steven Zvi Josefowicz
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Alexia Martínez de Paz or Steven Zvi Josefowicz.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Martínez de Paz, A., Josefowicz, S.Z. Gene regulatory networks STARR-ing B cells. Nat Immunol 21, 110–112 (2020). https://doi.org/10.1038/s41590-019-0566-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-019-0566-z

  • Springer Nature America, Inc.

Search

Navigation