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Slow phosphor-Y-LAT-ion for TCR ligand discrimination

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A report sheds new light on the molecular mechanisms responsible for the discrimination of self versus non-self TCR ligands and reveals the crucial role of the kinetics of LAT tyrosine phosphorylation in this.

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Fig. 1: The kinetics with which the sixth tyrosine of LAT is phosphorylated control the discrimination of TCR ligands.

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Authors and Affiliations

  1. Institute of Biomedical Research Cadiz (INIBICA), Cádiz, Spain

    Enrique Aguado & Mikel M. Arbulo-Echevarria

  2. Department of Biomedicine, Biotechnology and Public Health (Immunology), University of Cádiz, Cádiz, Spain

    Enrique Aguado

Authors
  1. Enrique Aguado
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  2. Mikel M. Arbulo-Echevarria
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Correspondence to Enrique Aguado.

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The authors declare no competing interests.

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Aguado, E., Arbulo-Echevarria, M.M. Slow phosphor-Y-LAT-ion for TCR ligand discrimination. Nat Immunol 20, 1420–1422 (2019). https://doi.org/10.1038/s41590-019-0522-y

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