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HIV IMMUNITY

A SNP of lncRNA gives HIV-1 a boost

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Although the molecular basis of most disease-associated single-nucleotide polymorphisms has remained elusive, an HIV-1 viral load–associated polymorphism (rs1015164) has been identified that marks expression of a long non-coding RNA that regulates the co-receptor CCR5 and thereby influences infection of CD4+ T cells.

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Fig. 1: Molecular basis for the association of the SNP rs1015164A/G with HIV-1 disease progression.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA

    Sanath Kumar Janaka & David T. Evans

  2. Wisconsin National Primate Research Center, Madison, WI, USA

    David T. Evans

Authors
  1. Sanath Kumar Janaka
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  2. David T. Evans
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Correspondence to David T. Evans.

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The authors declare no competing interests.

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Janaka, S.K., Evans, D.T. A SNP of lncRNA gives HIV-1 a boost. Nat Immunol 20, 778–780 (2019). https://doi.org/10.1038/s41590-019-0422-1

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  • DOI: https://doi.org/10.1038/s41590-019-0422-1

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