The cytokine IL-17 augments metabolism in fibroblastic reticular cells in lymph nodes, which enhances their proliferation and survival to support B cell responses during autoimmunity.
References
Veldhoen, M. Nat. Immunol. 18, 612–621 (2017).
Majumder, S. et al. Nat. Immunol. https://doi.org/10.1038/s41590-019-0367-4 (2019).
Alexandre, Y. O. & Mueller, S. N. Immunol. Rev. 283, 77–85 (2018).
Goverman, J. Nat. Rev. Immunol. 9, 393–407 (2009).
Yang, C. Y. et al. Proc. Natl Acad. Sci. USA 111, E109–E118 (2014).
Gregory, J. L. et al. Cell Rep. 18, 406–418 (2017).
Chyou, S. et al. J. Immunol. 187, 5558–5567 (2011).
Cremasco, V. et al. Nat. Immunol. 15, 973–981 (2014).
Dubey, L. K. et al. Cell Rep. 15, 1527–1541 (2016).
Astarita, J. L. et al. Nat. Immunol. 16, 75–84 (2015).
Acton, S. E. et al. Nature 514, 498–502 (2014).
Pikor, N. B. et al. Immunity 43, 1160–1173 (2015).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Mueller, S.N. IL-17 instructs lymphoid stromal cells. Nat Immunol 20, 524–526 (2019). https://doi.org/10.1038/s41590-019-0375-4
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41590-019-0375-4
- Springer Nature America, Inc.
This article is cited by
-
Post-transcriptional checkpoints in autoimmunity
Nature Reviews Rheumatology (2023)
-
The IL-17 family in diseases: from bench to bedside
Signal Transduction and Targeted Therapy (2023)