Skip to main content

Advertisement

SpringerLink
Log in

TUMOR IMMUNOEVASION

Tumors sweeten macrophages with acids

  • News & Views
  • Published:

From Nature Immunology

View current issue Submit your manuscript

Acidic microenvironments induced by highly glycolytic tumor cells promote the noninflammatory polarization of tumor-associated macrophages, which leads to immunoevasion.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Instruction of macrophages by the acidification of tumor microenvironments.

References

  1. Walenta, S. et al. Cancer Res. 60, 916–921 (2000).

    CAS  PubMed  Google Scholar 

  2. Bohn et al. Nat. Immunol. https://doi.org/10.1038/s41590-018-0226-8 (2018).

    Article  PubMed  Google Scholar 

  3. Chen, D. S. & Mellman, I. Nature 541, 321–330 (2017).

    Article  CAS  Google Scholar 

  4. Seliger, B. et al. Eur. J. Immunol. 28, 122–133 (1998).

    Article  CAS  Google Scholar 

  5. Kitamura, H., Onodera, Y., Murakami, S., Suzuki, T. & Motohashi, H. Oncogene 36, 6315–6324 (2017).

    Article  CAS  Google Scholar 

  6. DeBerardinis, R. J. & Chandel, N. S. Sci. Adv. 2, e1600200 (2016).

    Article  Google Scholar 

  7. Hirschhaeuser, F., Sattler, U. G. & Mueller-Klieser, W. Cancer Res. 71, 6921–6925 (2011).

    Article  CAS  Google Scholar 

  8. Colegio, O. R. et al. Nature 513, 559–563 (2014).

    Article  CAS  Google Scholar 

  9. Chang, C. H. et al. Cell 162, 1229–1241 (2015).

    Article  CAS  Google Scholar 

  10. Buck, M. D., Sowell, R. T., Kaech, S. M. & Pearce, E. L. Cell 169, 570–586 (2017).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan

    Hiroki Sekine & Hozumi Motohashi

  2. Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan

    Masayuki Yamamoto

Authors
  1. Hiroki Sekine
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Masayuki Yamamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hozumi Motohashi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hozumi Motohashi.

Ethics declarations

Competing interests

The authors declare no competing interests

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sekine, H., Yamamoto, M. & Motohashi, H. Tumors sweeten macrophages with acids. Nat Immunol 19, 1281–1283 (2018). https://doi.org/10.1038/s41590-018-0258-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-018-0258-0

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation