Single-cell transcriptomic analysis shows that B cells experience a continuum of cyclic transitional states during the germinal center (GC) reaction; this pattern is lost in GC-derived follicular lymphoma cells, which seem to be heterogeneous and desynchronized.
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References
Victora, G. D. & Nussenzweig, M. C. Annu. Rev. Immunol. 30, 429–457 (2012).
Basso, K. & Dalla-Favera, R. Nat. Rev. Immunol. 15, 172–184 (2015).
Milpied, P. et al. Nat. Immunol. https://doi.org/10.1038/s41590-018-0181-4 (2018).
McHeyzer-Williams, L. J., Milpied, P. J., Okitsu, S. L. & McHeyzer-Williams, M. G. Nat. Immunol. 16, 296–305 (2015).
Victora, G. D. et al. Cell 143, 592–605 (2010).
Calado, D. P. et al. Nat. Immunol. 13, 1092–1100 (2012).
Dominguez-Sola, D. et al. Nat. Immunol. 13, 1083–1091 (2012).
Angelin-Duclos, C., Cattoretti, G., Lin, K. I. & Calame, K. J. Immunol. 165, 5462–5471 (2000).
Victora, G. D. et al. Blood 120, 2240–2248 (2012).
Alizadeh, A. A. et al. Nature 403, 503–511 (2000).
Kridel, R., Sehn, L. H. & Gascoyne, R. D. J. Clin. Invest. 122, 3424–3431 (2012).
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Basso, K. Singling out the out-of-tune in lymphoma. Nat Immunol 19, 903–905 (2018). https://doi.org/10.1038/s41590-018-0189-9
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DOI: https://doi.org/10.1038/s41590-018-0189-9
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