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T CELL MOTILITY

CCR7 fuels and LFA-1 grips

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Naive T cells migrate rapidly through the lymph node. A high-resolution look at the chemokine receptor CCR7 and integrin LFA-1 reveals that T cells remain highly responsive to their microenvironment via instantaneous tuning of chemokine-regulated actin flow and integrin-regulated adhesion.

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Fig. 1: The balance of actin retrograde flow and adhesion regulates migration efficiency.

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Authors and Affiliations

  1. Department of Physics and Astronomy and Department of Biology, University of Rochester, Rochester, NY, USA

    Patrick W. Oakes

  2. David H. Smith Center for Vaccine Biology and immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA

    Deborah J. Fowell

Authors
  1. Patrick W. Oakes
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  2. Deborah J. Fowell
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Corresponding author

Correspondence to Deborah J. Fowell.

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The authors declare no competing interests.

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Oakes, P.W., Fowell, D.J. CCR7 fuels and LFA-1 grips. Nat Immunol 19, 516–518 (2018). https://doi.org/10.1038/s41590-018-0118-y

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  • DOI: https://doi.org/10.1038/s41590-018-0118-y

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