γδ T cells accumulate with age in adipose tissue and produce the cytokine IL-17, which controls the homeostasis of regulatory T cells and adaptive thermogenesis. Thus, maintenance of core body temperature unexpectedly relies on these adipose tissue–resident γδ17 T cells.
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Papotto, P.H., Silva-Santos, B. Got my γδ17 T cells to keep me warm. Nat Immunol 19, 427–429 (2018). https://doi.org/10.1038/s41590-018-0090-6
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DOI: https://doi.org/10.1038/s41590-018-0090-6
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