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TFH CELL DIFFERENTIATION

Is it dead or alive? TLR8 can tell

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The sensing of viable pathogens by the receptor TLR8 on human monocytes provides key signals that initiate the differentiation of naive CD4+ T cells into follicular helper T cells. Targeting TLR8 might represent a novel approach for improving immunity following vaccination.

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Fig. 1: TLR8-medited induction of IL-12 drives a TFH cell program in naive human CD4+ T cells.

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Authors and Affiliations

  1. Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

    Stuart G. Tangye

  2. St Vincent’s Clinical School, University of New South Wales, Darlinghurst, NSW, Australia

    Stuart G. Tangye

Authors
  1. Stuart G. Tangye
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Correspondence to Stuart G. Tangye.

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Tangye, S.G. Is it dead or alive? TLR8 can tell. Nat Immunol 19, 324–326 (2018). https://doi.org/10.1038/s41590-018-0070-x

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  • DOI: https://doi.org/10.1038/s41590-018-0070-x

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