Skip to main content
SpringerLink
Log in

Natural products

A peptide dehydratase with core strength

  • News & Views
  • Published:

From Nature Chemical Biology

View current issue Submit your manuscript

Ribosomally synthesized and post-translationally modified peptide (RiPP) natural products typically rely on substrate recognition through remote protein–protein interaction sites. Now, an atypical dehydratase, whose activity is directed by neighboring azole modifications, has been shown to produce a highly modified peptide hybrid bearing dehydroamino acids, enabling the synthesis of members of the dehydrazole family of RiPPs.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Discovery of dehydrazole peptides through co-occurrence search for dehydrations and backbone cyclizations.

References

  1. Montalbán-López, M. et al. Nat. Prod. Rep. 38, 130–239 (2021).

    Article  PubMed  Google Scholar 

  2. Kautsar, S. A., Blin, K., Shaw, S., Weber, T. & Medema, M. H. Nucleic Acids Res. 49, D490–D497 (2020).

    Article  PubMed Central  Google Scholar 

  3. Pei, Z.-F., Zhu, L. & Nair, S. K. Nat. Commun. 14, 7734 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Repka, L. M., Chekan, J. R., Nair, S. K. & van der Donk, W. A. Chem. Rev. 117, 5457–5520 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Burkhart, B. J., Schwalen, C. J., Mann, G., Naismith, J. H. & Mitchell, D. A. Chem. Rev. 117, 5389–5456 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Igarashi, Y. et al. J. Antibiot. 54, 1045–1053 (2001).

    Article  CAS  Google Scholar 

  7. Pei, Z.-F., Yang, M.-J., Zhang, K., Jian, X.-H. & Tang, G.-L. Cell Chem. Biol. 29, 650–659 (2022).

    Article  CAS  PubMed  Google Scholar 

  8. Suzuki, M. et al. Appl. Microbiol. Biotechnol. 105, 93–104 (2021).

    Article  CAS  PubMed  Google Scholar 

  9. Vinogradov, A. A. & Suga, H. Cell Chem. Biol. 27, 1032–1051 (2020).

    Article  CAS  PubMed  Google Scholar 

  10. Huang, S. et al. Angew. Chem. Int. Ed. 61, e202211382 (2022).

    Article  CAS  Google Scholar 

  11. Rahman, I. R. et al. ACS Chem. Biol. 15, 1473–1486 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Walker, J. A. et al. ACS Cent. Sci. 8, 473–482 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Burkhart, B. J., Kakkar, N., Hudson, G. A., van der Donk, W. A. & Mitchell, D. A. ACS Cent. Sci. 3, 629–638 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Gross, E. & Morell, J. L. J. Am. Chem. Soc. 93, 4634–4635 (1997).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Zurich, Switzerland

    Daniel Richter & Anna Lisa Vagstad

Authors
  1. Daniel Richter
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Anna Lisa Vagstad
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Anna Lisa Vagstad.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Richter, D., Vagstad, A.L. A peptide dehydratase with core strength. Nat Chem Biol 20, 546–548 (2024). https://doi.org/10.1038/s41589-024-01605-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41589-024-01605-5

  • Springer Nature America, Inc.

Search

Navigation