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Innate immunity

LPS gets a fresh trim

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Detection of intracellular lipolysaccharide (LPS) activates an immune response initiated by the non-canonical inflammasome. ATGL has now been identified as a negative regulator of this pathway that dampens inflammation by removing LPS’ acyl chains, preventing the activation of inflammatory caspases and cytokines.

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Fig. 1: ATGL modulate LPS detection.

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Authors and Affiliations

  1. Department of Biology, University of York, York, UK

    Gemma Banister & Dave Boucher

  2. York Biomedical Research Institute, York, UK

    Dave Boucher

Authors
  1. Gemma Banister
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  2. Dave Boucher
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Correspondence to Dave Boucher.

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The authors declare no competing interests.

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Banister, G., Boucher, D. LPS gets a fresh trim. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-024-01589-2

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  • DOI: https://doi.org/10.1038/s41589-024-01589-2

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