An integrative approach has now enabled elucidation of the complete biosynthetic pathway of a prominent saponin adjuvant. Reconstruction of the whole biosynthetic pathway in a heterologous host provides new perspectives for the biotechnological supply of this immunostimulant.
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References
Pulendran, B., Arunachalam, P. S. & O’Hagan, D. T. Nat. Rev. Drug Discov. 20, 454–475 (2021).
Pifferi, C., Fuentes, R. & Fernández-Tejada, A. Nat. Rev. Chem. 5, 197–216 (2021).
Lau, W. & Sattely, E. S. Science 349, 1224–1228 (2015).
Srinivasan, P. & Smolke, C. D. Nature 585, 614–619 (2020).
Biggs, B. W. et al. Science 374, 1563–1565 (2021).
Martin, L. B. B. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-023-01538-5 (2024).
Reed, J. et al. Science 379, 1252–1264 (2023).
Zhang, J. et al. Nature 609, 341–347 (2022).
Medema, M. H., de Rond, T. & Moore, B. S. Nat. Rev. Genet. 22, 553–571 (2021).
Bradley, S. A. et al. Nat. Chem. Biol. 19, 1551–1560 (2023).
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Courdavault, V., Papon, N. Accessing natural vaccine adjuvants. Nat Chem Biol 20, 401–403 (2024). https://doi.org/10.1038/s41589-024-01585-6
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DOI: https://doi.org/10.1038/s41589-024-01585-6
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