BURP-domain proteins belong to an emerging class of autocatalytic copper-containing proteins that modify themselves after synthesis. Now, a report explains how their structure and metal coordination sphere control the installation of crosslinks within the core peptide, and shows how nature leverages mechanistic paradigms to create diversity.
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Blackburn, N.J. Ripping and stitching with copper. Nat Chem Biol 20, 404–405 (2024). https://doi.org/10.1038/s41589-024-01582-9
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DOI: https://doi.org/10.1038/s41589-024-01582-9
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