Kir4.1 potassium channels expressed in astroglial cells critically regulate extracellular potassium concentration in the brain. A new study reports that blocking the flow of potassium ions into astrocytes by inhibiting Kir4.1 induces rapid-onset antidepressive effects in rodents.
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Denton, J.S. Dam antidepressants. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-024-01567-8
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DOI: https://doi.org/10.1038/s41589-024-01567-8
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