Inhibitors of KRAS G12C have shown that directly targeting RAS is possible, but G12C is only one of many RAS driver mutations. Covalent targeting of another major variant, G12D, raises hope for treating other groups of patients with KRAS-mutant tumors.
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K.W. serves on advisory boards for Vibliome Therapeutics, Reactive Biosciences and Velurum Therapeutics and has equity in Vibliome and Velurum. K.W. has received funding from Revolution Medicines and Astellas Pharmaceuticals. K.W. has served as a consultant for Sanofi, AstraZeneca and Amgen.
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Westover, K. Another KRAS variant trapped. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-024-01556-x
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DOI: https://doi.org/10.1038/s41589-024-01556-x
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