Macromolecules can undergo liquid–liquid phase separation to form condensates that have critical roles in biological functions and dysfunctions. A new study demonstrates that differences in micropolarity between components is a prime determinant of the multiphasic architecture of biomolecular condensates.
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References
Alberti, S. & Hyman, A. A. Nat. Rev. Mol. Cell Biol. 22, 196–213 (2021).
Lyon, A. S., Peeples, W. B. & Rosen, M. K. Nat. Rev. Mol. Cell Biol. 22, 215–235 (2021).
Feric, M. et al. Cell 165, 1686–1697 (2016).
Jain, S. et al. Cell 164, 487–498 (2016).
Ye, S. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-023-01477-1 (2023).
Shav-Tal, Y. et al. Mol. Biol. Cell 16, 2395–2413 (2005).
Bolen, D. W. & Baskakov, I. V. J. Mol. Biol. 310, 955–963 (2001).
Ferreon, J. C. et al. Int. J. Mol. Sci. 19, 1360 (2018).
Choi, K. J. et al. Biochemistry 57, 6822–6826 (2018).
Sharma, R. et al. Nat. Commun. 12, 5579 (2021).
Acknowledgements
Grant support was provided by NINDS, NIH to A.C.M.F. (R01 NS105874 and R21 NS107792), and by NIGMS, NIH (R01 GM122763) and the Welch Foundation (Q-2097-20220331) to J.C.F.
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Quan, M.D., Ferreon, J.C. & Ferreon, A.C.M. Micropolarized to the core. Nat Chem Biol 20, 399–400 (2024). https://doi.org/10.1038/s41589-024-01542-3
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DOI: https://doi.org/10.1038/s41589-024-01542-3
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