SRI-41315 is a small molecule that enhances premature read-through of the stop codon by triggering the degradation of the translation termination factor eRF1. Cryo-EM structures and biochemical analyses reveal how SRI-41315 acts as a molecular glue between eRF1 and the decoding center of ribosomes, leading to increased recognition of the cryptic stop codon and eRF1 degradation.
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References
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This is a summary of: Coelho, J. L. et al. The eRF1 degrader SRI-41315 acts as a molecular glue at the ribosomal decoding center. Nat. Chem. Biol. https://doi.org/10.1038/s41589-023-01521-0 (2024).
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A molecular glue degrader of eRF1 on the ribosome. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-023-01522-z
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DOI: https://doi.org/10.1038/s41589-023-01522-z
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