Skip to main content
SpringerLink
Log in

Sirtuin regulation

The buck stops with spermidine

  • News & Views
  • Published:

From Nature Chemical Biology

View current issue Submit your manuscript

Sirtuins remove post-translationally added acyl groups from protein lysines. New work shows the surprising metabolic fate of acyl groups removed from mitochondrial proteins—they react nonenzymatically with essential polyamine spermidine, forming previously unknown monoacylated N-glutarylspermidines and diacylated N-glutaryl,N-acetylspermidines.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Protein deacylation in mitochondria produces N-acylspermidines.

References

  1. James, A. M. et al. Trends Biochem. Sci. 43, 921–932 (2018).

    Article  CAS  PubMed  Google Scholar 

  2. Ringel, A. E., Tucker, S. A. & Haigis, M. C. Mol. Cell 72, 610–624 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Zhang, B. Nat. Chem. Biol. https://doi.org/10.1038/s41589-023-01511-2 (2024).

  4. Weiss, M. C. et al. Nat. Microbiol. 1, 16116 (2016).

    Article  CAS  PubMed  Google Scholar 

  5. Park, M. H. & Wolff, E. C. J. Biol. Chem. 293, 18710–18718 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Pegg, A. E. IUBMB Life 66, 8–18 (2014).

    Article  CAS  PubMed  Google Scholar 

  7. Casero, R. A. & Pegg, A. E. Biochem. J. 421, 323–338 (2009).

    Article  CAS  PubMed  Google Scholar 

  8. Hofer, S. J. et al. Nat. Aging 2, 1112–1129 (2022).

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Anthony J. Michael

Authors
  1. Anthony J. Michael
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Anthony J. Michael.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Michael, A.J. The buck stops with spermidine. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-023-01510-3

Download citation

  • Published:

  • DOI: https://doi.org/10.1038/s41589-023-01510-3

  • Springer Nature America, Inc.

Search

Navigation