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A new class of macrocyclic peptides

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Nature has evolved elegant enzymatic strategies to cyclize peptides, resulting in complex macrocyclic compounds with potent biological activities. A study illustrates the diverse chemical versatility of one such remarkable enzyme family, the cytochrome P450 macrocyclases, which form new biaryl crosslinks in ribosomal peptidic natural products.

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Fig. 1: Biosynthesis.
Fig. 2: Analysis of the activities of the P450s (SroB, PruB and SlpB).

References

  1. Bernhardt, R. J. Biotechnol. 124, 128–145 (2006).

    Article  CAS  PubMed  Google Scholar 

  2. Greule, A. et al. Nat. Prod. Rep. 35, 757–791 (2018).

    Article  CAS  PubMed  Google Scholar 

  3. Schramma, K. R. et al. Nat. Chem. 7, 431–437 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Montalban-Lopez, M. et al. Nat. Prod. Rep. 38, 130–239 (2021).

    Article  CAS  PubMed  Google Scholar 

  5. Nagano, N. et al. Fungal Genet. Biol. 86, 58–70 (2016).

    Article  CAS  PubMed  Google Scholar 

  6. Nam, H. et al. J. Am. Chem. Soc. 145, 22047–22057 (2023).

    Article  CAS  PubMed  Google Scholar 

  7. Nanudorn, P. et al. Angew. Chem. Int. Edn 61, e202208361 (2022).

    Article  CAS  Google Scholar 

  8. Hug, J. J. et al. ACS Chem. Biol. 15, 2221–2231 (2020).

    Article  CAS  PubMed  Google Scholar 

  9. Zdouc, M. M. et al. Cell Chem. Biol. 28, 733–739 (2021).

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Nilkamal Mahanta.

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Pattanayakanahalli Henjarappa, K., Das, S. & Mahanta, N. A new class of macrocyclic peptides. Nat Chem Biol 20, 136–139 (2024). https://doi.org/10.1038/s41589-023-01507-y

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