DNA-encoded libraries are a powerful tool to identify novel chemical inducers of proximity such as targeted protein degraders, even without a known binder for the target protein.
This is a preview of subscription content, log in via an institution to check access.
References
Schreiber, S. L. Cell 184, 3–9 (2021).
Liu, X. et al. ACS Cent. Sci. 9, 1269–1284 (2023).
Sakamoto, K. M. et al. Proc. Natl Acad. Sci. USA 98, 8554–8559 (2001).
Hendrick, C. E. et al. ACS Med. Chem. Lett. 13, 1182–1190 (2022).
Mason, J. W. et al. https://doi.org/10.1038/s41589-023-01458-4 (2023).
Krieger, J. et al. ChemMedChem. 18, e202200615 (2023).
Liu, S. et al. J. Am. Chem. Soc. 145, 23281–23291 (2023).
Chen, Q. et al. ACS Chem. Biol. 18, 25–33 (2023).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
Andrea Testa is an employee of Amphista Therapeutics Ltd.
Rights and permissions
About this article
Cite this article
Testa, A. Affinity for both sides. Nat Chem Biol 20, 134–135 (2024). https://doi.org/10.1038/s41589-023-01473-5
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41589-023-01473-5
- Springer Nature America, Inc.