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Synthetic biology

A PASS for protein secretion

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Traditional production of therapeutic secretory proteins often experiences delays between protein synthesis and therapeutic effects. An inducible protease-dependent protein secretion technique allows the immediate secretion of pre-translated biotherapeutic agents after exposure to chemical cues, tumor-specific antigens or photons.

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Fig. 1: Engineering the protein secretory pathway for programmable secretion of pre-translated therapeutic proteins.

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Authors and Affiliations

  1. Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, USA

    Tianlu Wang & Yubin Zhou

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  1. Tianlu Wang
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  2. Yubin Zhou
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Correspondence to Yubin Zhou.

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The authors declare no competing interests.

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Wang, T., Zhou, Y. A PASS for protein secretion. Nat Chem Biol 20, 396–398 (2024). https://doi.org/10.1038/s41589-023-01444-w

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