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Translational regulation

Switching on stress

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The integrated stress response affects cell survival or death under stress conditions, and depends on the activity of the eukaryotic translation initiation factor eIF2B. New research identifies a protein helix that modulates this response by controlling the structural states of eIF2B.

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Fig. 1: Proposed mechanism of ISR modulation by the switch-helix.

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Authors and Affiliations

  1. Laboratory for Translation Structural Biology, RIKEN Center for Biosystems Dynamics Research, Tsurumi-ku, Yokohama, Japan

    Kazuhiro Kashiwagi & Takuhiro Ito

Authors
  1. Kazuhiro Kashiwagi
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  2. Takuhiro Ito
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Correspondence to Takuhiro Ito.

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The authors declare no competing interests.

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Kashiwagi, K., Ito, T. Switching on stress. Nat Chem Biol 20, 394–395 (2024). https://doi.org/10.1038/s41589-023-01436-w

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  • DOI: https://doi.org/10.1038/s41589-023-01436-w

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