The susceptibility of nitric oxide (NO) to scavenging and oxidation limits its bioavailability and signaling role. New studies indicate that a NO–ferroheme adduct is resistant to such constraints and may serve as an alternative NO-derived signaling molecule in vasculature.
This is a preview of subscription content, log in via an institution to check access.
References
Murad, F. N. Engl. J. Med. 355, 2003–2011 (2006).
Batchelor, A. M. et al. Proc. Natl Acad. Sci. USA 107, 22060–22065 (2010).
DeMartino, A. W. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-023-01413-3 (2023).
Kleschyov, A. L. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-023-01411-5 (2023).
Ignarro, L. J. et al. J. Biol. Chem. 261, 4997–5002 (1986).
Wolin, M. S., Wood, K. S. & Ignarro, L. J. J. Biol. Chem. 257, 13312–13320 (1982).
Thoonen, R. et al. Nat. Commun. 6, 8482 (2015).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Martin, E. NO signal. Nat Chem Biol 19, 1178–1179 (2023). https://doi.org/10.1038/s41589-023-01421-3
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41589-023-01421-3
- Springer Nature America, Inc.