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Biomolecular condensates

RNA repeats stall translation

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CAG triple-nucleotide repeats in multiple genes have been linked to various human diseases. A recent study unveils the effects of CAG repeat RNA gelation on protein translation, thereby expanding our knowledge of CAG-elicited toxicities.

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Fig. 1: Toxicity of CAG repeats at DNA, RNA and protein levels.

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Authors and Affiliations

  1. School of Life Sciences, Westlake University, Hangzhou, China

    Zhenshuo Zhu & Peiguo Yang

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  1. Zhenshuo Zhu
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  2. Peiguo Yang
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Correspondence to Peiguo Yang.

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The authors declare no competing interests.

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Zhu, Z., Yang, P. RNA repeats stall translation. Nat Chem Biol 19, 1299–1300 (2023). https://doi.org/10.1038/s41589-023-01404-4

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