A study of drug-resistant lymphomas with hypermorphic mutations in PRC2 has identified a ‘methylation index’ by which cancer cells maintain optimal H3K27me3 levels for survival, emphasizing the importance of understanding how tumors adapt to changes in chromatin and to drug-resistance mutations.
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Reich, T.J., Lewis, P.W. A goldilocks amount of H3K27me3. Nat Chem Biol 19, 1046–1047 (2023). https://doi.org/10.1038/s41589-023-01295-5
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DOI: https://doi.org/10.1038/s41589-023-01295-5
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