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Synthetic biology

Synthesizing cellular LOGIC

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Engineering synthetic tools that facilitate decision-making in mammalian cells could enable myriad biomedical applications. Researchers have now developed a new system of inducer-controlled transcription factors to facilitate synthetic decision-making (LOGIC) in human cells based on modular protein-fusion cascades.

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Fig. 1: Exemplars of human LOGIC synthetic circuits.

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Authors and Affiliations

  1. Georgia Institute of Technology, School of Chemical & Biomolecular Engineering, Atlanta, GA, USA

    Brian D. Huang, Ana S. De Pereda & Corey J. Wilson

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  1. Brian D. Huang
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  2. Ana S. De Pereda
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  3. Corey J. Wilson
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Correspondence to Corey J. Wilson.

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The authors declare no competing interests.

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Huang, B.D., De Pereda, A.S. & Wilson, C.J. Synthesizing cellular LOGIC. Nat Chem Biol 19, 671–672 (2023). https://doi.org/10.1038/s41589-023-01280-y

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