Metabolic rewiring of activated macrophages promotes glycolysis and contributes to bacterial killing. A new study shows that reactive nitrogen species, released during macrophage activation, induce a profound inhibitory signal that facilitates metabolic reprogramming by modification of lipoate.
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Nathan, J.A. Nitrosylation rewires metabolism. Nat Chem Biol 19, 253–254 (2023). https://doi.org/10.1038/s41589-022-01169-2
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DOI: https://doi.org/10.1038/s41589-022-01169-2
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