Skip to main content
SpringerLink
Log in

Androgen receptor signaling

Breaking apart condensates

  • News & Views
  • Published:

From Nature Chemical Biology

View current issue Submit your manuscript

Prostate tumors, resistant to current antiandrogen therapies, represent a serious clinical challenge. A new report identifies androgen-receptor-dependent liquid condensates as being responsible in part for therapeutic resistance, but, encouragingly, also reveals a novel vulnerability amenable to drug targeting.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Targeting androgen receptor liquid–liquid phase separation to switch off receptor activity in prostate cancer cells.

References

  1. Wang, B. et al. Signal Transduct. Target. Ther. 6, 290 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Stortz, M., Presman, D. M., Pecci, A., Levi, V. & Ruggieri, A. Biochem J. 478, 443–461 (2021).

    Article  CAS  PubMed  Google Scholar 

  3. Xie, J. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-022-01151-y (2022).

    Article  PubMed  Google Scholar 

  4. McEwan, I. J. Mol. Biosyst. 8, 82–90 (2012).

    Article  CAS  PubMed  Google Scholar 

  5. Asangani, I. et al. J. Biol. Chem. 296, 100240 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Bouchard, J. J. et al. Mol. Cell 72, 19–36 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Bielskutė, S. et al. Protein Sci. 30, 1427–1437 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Ahmed, J., Meszaros, A., Lazar, T. & Tompa, P. Protein Sci. 30, 1380–1392 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Andersen, R. J. et al. Cancer Cell 17, 535–546 (2010).

    Article  CAS  PubMed  Google Scholar 

  10. Ruggieri, A. & Stoecklin, G. Nat. Chem. Biol. 15, 5–6 (2019).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Medical Sciences, University of Aberdeen, Aberdeen, Scotland, UK

    Iain J. McEwan

Authors
  1. Iain J. McEwan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Iain J. McEwan.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

McEwan, I.J. Breaking apart condensates. Nat Chem Biol 18, 1292–1293 (2022). https://doi.org/10.1038/s41589-022-01161-w

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41589-022-01161-w

  • Springer Nature America, Inc.

Search

Navigation