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POST-TRANSLATIONAL MODIFICATIONS

Catch your breath

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Carbon dioxide (CO2) is a product of cellular respiration that can also serve as a post-translational modification (PTM) through covalent protein modification. A new chemoproteomic strategy enables the capture of functional CO2-dependent carboxylation on lysine residues of proteins.

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Fig. 1: Homocitrullination enables chemoproteomic identification of CO2-reactive lysines through competitive labeling.

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Authors and Affiliations

  1. Department of Chemistry, University of Virginia, Charlottesville, VA, USA

    R. Justin Grams & Ku-Lung Hsu

  2. Department of Pharmacology, , University of Virginia School of Medicine, Charlottesville, VA, USA

    Ku-Lung Hsu

  3. Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA

    Ku-Lung Hsu

  4. University of Virginia Cancer Center, University of Virginia, Charlottesville, VA, USA

    Ku-Lung Hsu

Authors
  1. R. Justin Grams
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  2. Ku-Lung Hsu
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Correspondence to Ku-Lung Hsu.

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The authors declare no competing interests.

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Grams, R.J., Hsu, KL. Catch your breath. Nat Chem Biol 18, 686–687 (2022). https://doi.org/10.1038/s41589-022-01063-x

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