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SYNTHETIC BIOLOGY

CAR-T cells SEAK help from enzymes

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Chimeric antigen receptor T cells (CAR-T cells) are often hindered by the concurrent challenges of variable antigen expression patterns and immunosuppressive tumor microenvironments. A new approach enhances CAR-T cells by coexpressing bacterial enzymes that activate prodrugs in high concentrations at the disease site.

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Fig. 1: 'SEAKER' cells for dual-mode tumor lysis.

References

  1. Gardner, T. J. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-021-00932-1 (2021).

  2. Majzner, R. G. & Mackall, C. L. Cancer Discov. 8, 1219–1226 (2018).

    Article  CAS  Google Scholar 

  3. Hyrenius-Wittsten, A. & Roybal, K. T. Trends. Cancer 5, 583–592 (2019).

    Article  CAS  Google Scholar 

  4. Gardner, T. J. et al. Cancers 12, 2175 (2020).

    Article  CAS  Google Scholar 

  5. Sharma, S. K. & Bagshawe, K. D. Expert Opin. Biol. Th. 17, 1–13 (2016).

    Article  Google Scholar 

  6. Roybal, K. T. et al. Cell 167, 419–432.e16 (2016).

    Article  CAS  Google Scholar 

  7. Choi, B. D. et al. Nat. Biotechnol. 37, 1049–1058 (2019).

    Article  CAS  Google Scholar 

  8. Sukumaran, S. et al. Cancer Discov. 8, 972–987 (2018).

    Article  CAS  Google Scholar 

  9. Huang, X. et al. Nat. Nanotechnol. 16, 214–223 (2021).

    Article  CAS  Google Scholar 

  10. Park, A. K. et al. Science Transl. Med. 12, eaaz1863 (2020).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Biomedical Engineering, Columbia University, New York, NY, USA

    Rosa Vincent & Tal Danino

  2. Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA

    Tal Danino

  3. Data Science Institute, Columbia University, New York, NY, USA

    Tal Danino

Authors
  1. Rosa Vincent
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  2. Tal Danino
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Corresponding author

Correspondence to Tal Danino.

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The authors declare no competing financial interests.

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Vincent, R., Danino, T. CAR-T cells SEAK help from enzymes. Nat Chem Biol 18, 122–123 (2022). https://doi.org/10.1038/s41589-021-00933-0

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  • DOI: https://doi.org/10.1038/s41589-021-00933-0

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