The molecular mechanism through which chromatin-bound RNA-binding proteins (chrRBPs) control transcription remains obscure. A new study reveals that chrRBPs can compartmentalize RNA and transcription machinery into a phase-separated condensate, thus modulating gene expression.
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Li, C., Lu, H. Rolling the RBP snowballs. Nat Chem Biol 18, 5–6 (2022). https://doi.org/10.1038/s41589-021-00902-7
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DOI: https://doi.org/10.1038/s41589-021-00902-7
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