References
You, W. & Steegborn, C. Binding site for MDL-801 on SIRT6. Nat. Chem. Biol. https://doi.org/10.1038/s41589-021-00749-y (2021).
Huang, Z. et al. Identification of a cellularly active SIRT6 allosteric activator. Nat. Chem. Biol. 14, 1118–1126 (2018).
Jiang, H. et al. SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine. Nature 496, 110–113 (2013).
Author information
Authors and Affiliations
Contributions
Z.H., J.S. and K.S. performed the biological experiments and the crystallography. K.S. solved the crystal structures and analyzed the data. J. Zhang, S.L. and H.S. discussed the manuscript, J. Zhang and S.L. wrote the manuscript and J. Zhao, W.D., Y.C., L.Z., C.W., X.Y., B.H., J.M., H.H., M.T., J.X., Q.Z., J. Zhong, X.S., Z.M., H.L., M.X., Y.E.C., H.J., Y.X. and G.C. are the authors of our previous paper2.
Corresponding author
Ethics declarations
Competing interests
The group of J. Zhang has a collaboration with Shanghai Ailewei on SIRT6.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Supplementary information
Supplementary Information
Supplementary Table 1.
Rights and permissions
About this article
Cite this article
Huang, Z., Zhao, J., Deng, W. et al. Reply to: Binding site for MDL-801 on SIRT6. Nat Chem Biol 17, 522–523 (2021). https://doi.org/10.1038/s41589-021-00750-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41589-021-00750-5
- Springer Nature America, Inc.