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UBIQUITIN TRANSFER

Advanced rules of relays

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Transfer of ubiquitin onto target proteins requires controlled interplay between E2 conjugating enzymes and E3 ligases. The structure of a trapped E2~Ub/RCR E3 transfer intermediate provides novel insight into the diversity of mechanisms used to fine tune this relay.

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Fig. 1: Schematic of ubiquitin ligase (E3) mechanisms, featuring the interactions of the catalytic region of the respective E3 with a ubiquitin (Ub)-loaded E2.

References

  1. Mabbitt, P. D. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-020-0598-6 (2020)

  2. Buetow, L. & Huang, D. T. Nat. Rev. Mol. Cell Biol. 17, 626–642 (2016).

    Article  CAS  Google Scholar 

  3. Lorenz, S. Biol. Chem. 399, 127–145 (2018).

    Article  CAS  Google Scholar 

  4. Dove, K. K. & Klevit, R. E. J. Mol. Biol. 429, 3363–3375 (2017).

    Article  CAS  Google Scholar 

  5. Walden, H. & Rittinger, K. Nat. Struct. Mol. Biol. 25, 440–445 (2018).

    Article  CAS  Google Scholar 

  6. Pao, K. C. et al. Nat. Chem. Biol. 12, 324–331 (2016).

    Article  CAS  Google Scholar 

  7. Pao, K. C. et al. Nature 556, 381–385 (2018).

    Article  CAS  Google Scholar 

  8. Ahel, J. et al. eLife 9, e56185 (2020).

    Article  Google Scholar 

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Authors and Affiliations

  1. Rudolf Virchow Center, University of Würzburg, Würzburg, Germany

    Sonja Lorenz

  2. Molecular Structure of Cell Signalling Laboratory, The Francis Crick Institute, London, UK

    Katrin Rittinger

Authors
  1. Sonja Lorenz
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  2. Katrin Rittinger
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Corresponding authors

Correspondence to Sonja Lorenz or Katrin Rittinger.

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The authors declare no competing interests.

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Lorenz, S., Rittinger, K. Advanced rules of relays. Nat Chem Biol 16, 1158–1159 (2020). https://doi.org/10.1038/s41589-020-0632-8

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  • DOI: https://doi.org/10.1038/s41589-020-0632-8

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