A chemical screen identifies BET bromodomain inhibitors as inducers of an activated skin keratinocyte state that promotes the wound-healing capabilities of these cells. The study implicates epigenetic modifiers as potential targets for non-healing, chronic wounds.
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References
Biggs, L. C., Kim, C. S., Miroshnikova, Y. A. & Wickström, S. A. J. Invest. Dermatol. 140, 284–290 (2020).
Eming, S. A., Martin, P. & Tomic-Canic, M. Sci. Transl. Med. 6, 265sr6 (2014).
Lewis, C. J., Stevenson, A., Fear, M. W. & Wood, F. M. Wound Repair Regen. 28, 710–718 (2020).
Schutzius, G. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-020-00716-z (2020).
Pastar, I. et al. Adv. Wound Care (New Rochelle) 3, 445–464 (2014).
Muller, S., Filippakopoulos, P. & Knapp, S. Expert Rev. Mol. Med. 13, e29 (2011).
Pérez-Salvia, M. & Esteller, M. Epigenetics 12, 323–339 (2017).
Pervaiz, M., Mishra, P. & Günther, S. Chem. Rec. 18, 1808–1817 (2018).
Miroshnikova, Y. A., Cohen, I., Ezhkova, E. & Wickström, S. A. Curr. Opin. Genet. Dev. 55, 46–51 (2019).
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Ylivinkka, I., Wickström, S.A. BETting against wound healing. Nat Chem Biol 17, 233–235 (2021). https://doi.org/10.1038/s41589-020-00709-y
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DOI: https://doi.org/10.1038/s41589-020-00709-y
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