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Tailor-made GPCRs

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An in silico directed evolution approach using first principles of allostery predicts the effects of protein sequence and structure variation on constitutive activity and ligand response in GPCRs.

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Fig. 1: Repurposing GPCRs by focusing on conformational stability and allosteric networks.

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  1. Departments of Chemistry and Biochemistry, University of Toronto, Toronto, Canada

    R. Scott Prosser

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  1. R. Scott Prosser
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Correspondence to R. Scott Prosser.

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Prosser, R.S. Tailor-made GPCRs. Nat Chem Biol 16, 5–6 (2020). https://doi.org/10.1038/s41589-019-0427-y

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