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Antibody–drug conjugates

Breaking up is hard to do

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A comprehensive genetic screen reveals new cellular trafficking factors and linker-dependent requirements for antibody–drug conjugate (ADC) cytotoxicity. These new insights may guide the design of optimized ADCs.

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Fig. 1: Mechanisms for drug release from antibody–drug conjugates.

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Authors and Affiliations

  1. Seattle Genetics, Bothell, WA, USA

    Heather A. Van Epps & Peter D. Senter

Authors
  1. Heather A. Van Epps
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  2. Peter D. Senter
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Corresponding author

Correspondence to Peter D. Senter.

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Competing interests

The authors are employees of Seattle Genetics, a company engaged in the field of antibody–drug conjugates.

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Van Epps, H.A., Senter, P.D. Breaking up is hard to do. Nat Chem Biol 15, 934–935 (2019). https://doi.org/10.1038/s41589-019-0351-1

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  • DOI: https://doi.org/10.1038/s41589-019-0351-1

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