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PROTEIN KINASES

ARGuing for a new kinase class

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Arginine protein kinases regulate bacterial signaling cascades through phosphorylation of key arginine residues. Crystal structures of the kinase McsB provide the first glimpse of how these unusual enzymes recognize their protein substrates and are allosterically regulated.

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Fig. 1: Structure of activated McsB dimer.

References

  1. Pawson, T. & Scott, J. D. Science 278, 2075–2080 (1997).

    Article  CAS  Google Scholar 

  2. Knighton, D. R. et al. Science 253, 407–414 (1991).

    Article  CAS  Google Scholar 

  3. Trentini, D. B. et al. Nature 539, 48–53 (2016).

    Article  CAS  Google Scholar 

  4. Elsholz, A. K. et al. Proc. Natl Acad. Sci. USA 109, 7451–7456 (2012).

    Article  CAS  Google Scholar 

  5. Fuhrmann, J. et al. Science 324, 1323–1327 (2009).

    Article  CAS  Google Scholar 

  6. Suskiewicz, M.J. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-019-0265-y (2019).

    Article  Google Scholar 

  7. Adams, J. A. Chem. Rev. 101, 2271–2290 (2001).

    Article  CAS  Google Scholar 

  8. Hammarén, H. M., Virtanen, A. T. & Silvennoinen, O. Biosci. Rep. 36, e00282 (2015).

    Article  Google Scholar 

  9. Ellington, W. R. Annu. Rev. Physiol. 63, 289–325 (2001).

    Article  CAS  Google Scholar 

  10. Yousef, M. S., Fabiola, F., Gattis, J. L., Somasundaram, T. & Chapman, M. S. Acta Crystallogr. D Biol. Crystallogr. 58, 2009–2017 (2002).

    Article  Google Scholar 

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Correspondence to Titus J. Boggon.

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Boggon, T.J. ARGuing for a new kinase class. Nat Chem Biol 15, 431–432 (2019). https://doi.org/10.1038/s41589-019-0272-z

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