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CELL DEATH

Tightening a deadly pore former

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A small molecule was identified that binds to a unique site on the pro-apoptotic protein BAX, stabilizing the protein structure allosterically and preventing the conformational activation to a pore former by BH3 proteins.

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Fig. 1: A small molecule protein stabilizer prevents proapoptotic BAX pore formation in the mitochondrial membrane.

References

  1. Fricker, M., Tolkovsky, A. M., Borutaite, V., Coleman, M. & Brown, G. C. Physiol. Rev. 98, 813–880 (2018).

    Article  CAS  Google Scholar 

  2. Whelan, R. S., Kaplinskiy, V. & Kitsis, R. N. Annu. Rev. Physiol. 72, 19–44 (2010).

    Article  CAS  Google Scholar 

  3. Garner, T. P. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-018-0223-0 (2019).

    Article  PubMed  Google Scholar 

  4. Ashkenazi, A., Fairbrother, W. J., Leverson, J. D. & Souers, A. J. Nat. Rev. Drug Discov. 16, 273–284 (2017).

    Article  CAS  Google Scholar 

  5. Niu, X. et al. Cell Chem. Biol. 24, 493–506.e5 (2017).

    Article  CAS  Google Scholar 

  6. Gavathiotis, E. et al. Nature 455, 1076–1081 (2008).

    Article  CAS  Google Scholar 

  7. Czabotar, P. E. et al. Cell 152, 519–531 (2013).

    Article  CAS  Google Scholar 

  8. Barclay, L. A. et al. Mol. Cell 57, 873–886 (2015).

    Article  CAS  Google Scholar 

  9. Ma, J. et al. Proc. Natl Acad. Sci. USA 109, 20901–20906 (2012).

    Article  CAS  Google Scholar 

  10. Whelan, R. S. et al. Proc. Natl Acad. Sci. USA 109, 6566–6571 (2012).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, and Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

    Jialing Lin

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  1. Jialing Lin
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Correspondence to Jialing Lin.

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The author declares no competing interests.

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Lin, J. Tightening a deadly pore former. Nat Chem Biol 15, 316–317 (2019). https://doi.org/10.1038/s41589-019-0235-4

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