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The substrate lends a hand

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Duramycin is a small post-translationally modified peptide with antibody-like affinity for phosphatidylethanolamine. As it turns out, the same functionality that is essential for duramycin activity helps to catalyze the formation of its conformationally constrained and compact polycyclic architecture.

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Fig. 1: Structure and mechanism of DurN-catalyzed lysinoalanine formation.


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Correspondence to Albert A. Bowers.

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Bowers, A.A. The substrate lends a hand. Nat Chem Biol 14, 907–908 (2018).

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