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An optical sensor to monitor dynamics of extracellular glycine

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A computational design approach was used to develop a genetically encoded FRET-based optical sensor that is aimed at monitoring extracellular glycine levels in brain tissue with the sensitivity and resolution to discern differences in dendritic spine and shaft environment and concentration dynamics upon afferent stimulation.

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Fig. 1: An optical sensor to monitor glycine levels in the brain.

References

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Authors and Affiliations

  1. UCL Queen Square Institute of Neurology, University College London, Queen Square, London, UK

    Dmitri A. Rusakov

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  1. Dmitri A. Rusakov
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Correspondence to Dmitri A. Rusakov.

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Rusakov, D.A. An optical sensor to monitor dynamics of extracellular glycine. Nat Chem Biol 14, 835–836 (2018). https://doi.org/10.1038/s41589-018-0123-3

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